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Free Radic Biol Med (2009) 47(4):33343
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GLP-1 receptor activation inhibits hunger-promoting neurons while stimulating satiety-promoting neurons, creating a coordinated anorexigenic effect
66 In a randomized, controlled phase 3 study by Jastreboff et al, no difference in gallbladder stone rates was observed between 5, 10, and 15 mg tirzepatide treatment and placebo in obese individuals over 72 weeks
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